TP53 Abnormality in Myelodysplastic Syndrome
نویسندگان
چکیده
منابع مشابه
Lack of association between MDM2 SNP309 and TP53 Arg72Pro polymorphisms with clinical outcomes in myelodysplastic syndrome.
MDM2/p53 pathway plays an important role in the control of apoptotic and proliferation mechanisms, and alterations in this pathway have been described in myelodysplastic syndromes (MDS). We investigated the frequency of MDM2 SNP309, TP53 Arg72Pro polymorphisms in de novo MDS and the association of these polymorphisms with clinical characteristics. Our results showed that the frequencies of geno...
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Bo-Young Seo, M.D., Jun-Hyoung Lee, M.D., Min-Gu Kang, M.D., Seok-Yong Choi, M.D., Soo-Hyun Kim, M.D., Jong-Hee Shin, M.D., Soon-Pal Suh, M.D., Dong-Wook Ryang, M.D., and Myung-Geun Shin, M.D. Department of Laboratory Medicine, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun; Environmental Health Center for Childhood Leukemia and Cancer, Chonna...
متن کاملThe relationship of TP53 R72P polymorphism to disease outcome and TP53 mutation in myelodysplastic syndromes
Nonsynonymous TP53 exon 4 single-nucleotide polymorphism (SNP), R72P, is linked to cancer and mutagen susceptibility. R72P associations with specific cancer risk, particularly hematological malignancies, have been conflicting. Myelodysplastic syndrome (MDS) with chromosome 5q deletion is characterized by erythroid hypoplasia arising from lineage-specific p53 accumulation resulting from ribosoma...
متن کاملTP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.
BACKGROUND The molecular determinants of clinical responses to decitabine therapy in patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) are unclear. METHODS We enrolled 84 adult patients with AML or MDS in a single-institution trial of decitabine to identify somatic mutations and their relationships to clinical responses. Decitabine was administered at a dose of 20 ...
متن کاملTP53 mutations emerge at early phase of myelodysplastic syndrome and are associated with complex chromosomal abnormalities.
We examined TP53 mutation in 57 patients with myelodysplastic syndrome (MDS) at either the MDS phase or at the terminal leukemic phase using polymerase chain reaction-mediated single-strand conformation polymorphism (PCR-SSCP) analysis. TP53 mutations within exons 5 through 8 were found in seven patients. All these mutations were detected at the presentation of MDS whether these patients showed...
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ژورنال
عنوان ژورنال: Blood
سال: 2019
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2019-128054